Police say a speeding Lexus started the collision chain that shut down westbound Dublin Boulevard for hours.
A motorcycle shooting near California Avenue and a separate pileup near Ashland Avenue forced overnight closures on I-290.
CHP says investigators are still working to determine what caused the wreck near the metering lights.
Seven people were involved in the Saturday night collision, and investigators had not yet said what caused it.
A high-speed single-car crash on State Route 60 left a 24-year-old driver dead and an infant with minor injuries.
CHP says one other person survived the early Monday wreck at Road 60 and Avenue 328.
Authorities say the electric Class 8 truck struck two passenger vehicles in a deadly collision near Reno, and the cause remains under investigation.
Emergency crews responded before dawn Friday after a collision set one vehicle on fire and forced temporary road closures.