Authorities say the off-road vehicle overturned near 185th Avenue and Deer Valley Road, leaving one person dead and another hospitalized.
Authorities said at least one vehicle caught fire near McClintock Drive, forcing a long closure on the westbound freeway.
A morning crash and a separate injury collision slowed traffic across several East Bay corridors, including the Bay Bridge approach.
A Sunday afternoon collision left a motorcyclist dead, burned a Subaru, and forced traffic onto Constantia Road while crews cleared the scene.
California Highway Patrol is investigating the collision after one driver died and two people were hurt near Robinson Ranch Road.
A two-car collision at Naglee and Park avenues left one passenger dead and four other people hurt early Sunday.
The collision closed a lane and sent wreckage off the roadway as investigators worked to determine what caused the crash.
Authorities say investigators identified multiple alleged victims and are urging others to come forward.